Dr. CHEN Xiaohua

Associate professor

 chen_xh@qibebt.ac.cn, 086-0532-80662655

She obtained her bachelor for clinical medicine from Shanghai Second Medical University, and then went to Germany in 1995,where she got Master and PhD with specialization for molecular biology in Humboldt University of Berlin. Since 2003 -2011 she worked at the Humboldt University of Berlin as research associate. Her major research interest was in microbial genomes sequencing, functional genomics, and mechanisms of biosynthesis and regulation of secondary metabolites.

Since she moved to QIBEBT, she is focusing on the following research areas:

1.Using high-throughput-Screening combined with metagenomic techniques to identify more efficient cellulose degrading thermophil bacteria

2.Functional genomics in syngas utilizing bacterial and cellulose degrading bacteria (such as thermophilic and other extremphilic microorganisms)

3.Genetic engineering bio-energy producing bacteria (using Bacillus, E. coli as model strains)

4.Mechanism and regulation of antibiotic biosynthesis in Bacillus (mainly polykeitides) as well as bio-engineering polyketides

PUBILICATIONS:

1.  Borriss R, Chen XH, Rueckert C, Blom J , Becker A, Baumgarth B, Fan B, Pukall R, Schumann P, Spröer C, Junge H, Vater J, Pühler A, Klenk HP. Relationship of Bacillus amyloliquefaciens clades associated 1 with strains DSM 7T and FZB42: a proposal for Bacillus amyloliquefaciens subsp. amyloliquefaciens subsp. nov. and Bacillus amyloliquefaciens subsp. plantarum subsp. nov. based on their discriminating complete genome sequences. Int J Syst Evol Microbiol. 2010 Sep 3.

2.  Fan B, Chen XH, Budiharjo A; Bleiss W, Vater J, Borriss R. Efficient colonization of plant roots by the plant growth promoting bacterium Bacillus amyloliquefaciens FZB42, engineered to express green fluorescent protein. J Biotechnol. 2011 Jan 13.

3.  Rückert C, Blom J, Chen XH, Reva O, and Borriss R. Genome sequence of B. amyloliquefaciens type strain DSM7T reveals differences to plant-associated B. amyloliquefaciens FZB42. J Biotechnol. 2011 Jan 22. .

4.  Chen XH, Scholz R, Borriss M, Junge H, Mögel G, Kunz S, Borriss R. Difficidin and bacilysin produced by plant-associated Bacillus amyloliquefaciens are efficient in controlling fire blight disease. J Biotechnol. 2009 Mar 10; 140(1-2):38-44.

5.  Chen XH, Koumoutsi A, Scholz R, Schneider K, Vater J, Süssmuth R, Piel J, Borriss R. Genome analysis of Bacillus amyloliquefaciens FZB42 reveals its potential for biocontrol of plant pathogens. J Biotechnol. 2009 Mar 10; 140(1-2):27-37.

6.  Chen XH, Koumoutsi A, Scholz R, Borriss R. More than anticipated - production of antibiotics and other secondary metabolites by Bacillus amyloliquefaciens FZB42. J Mol Microbiol Biotechnol. 2009; 16(1-2):14-24.

7.  Moldenhauer J, Chen XH, Borriss R, Piel J. Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family. Angew Chem Int Ed Engl. 2007; 46(43):8195-7.

8.  Schneider K*, Chen XH*, Vater J, Franke P, Nicholson G, Borriss R, Süssmuth RD. Macrolactin is the polyketide biosynthesis product of the pks2 cluster of Bacillus amyloliquefaciens FZB42.  J Nat Prod. 2007 Sep; 70(9):1417-23. (* both contribute the same)

9.  Koumoutsi A, Chen XH, Vater J, Borriss R. DegU and YczE positively regulate the synthesis of bacillomycin D by Bacillus amyloliquefaciens strain FZB42. Appl Environ Microbiol. 2007 Nov; 73(21):6953-64.

10. Chen XH, Koumoutsi A, Scholz R, Eisenreich A, Schneider K, Heinemeyer I, Morgenstern B, Voss B, Hess WR, Reva O, Junge H, Voigt B, Jungblut PR, Vater J, Süssmuth R, Liesegang H, Strittmatter A, Gottschalk G, Borriss R. Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42. Nat Biotechnol. 2007 Sep; 25(9):1007-14.

11. Chen XH, Vater J, Piel J, Franke P, Scholz R, Schneider K, Koumoutsi A, Hitzeroth G, Grammel N, Strittmatter AW, Gottschalk G, Süssmuth RD, Borriss R. Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42. J Bacteriol. 2006 Jun; 188(11):4024-36.

12. Lund P, Weisshaupt K, Mikeska T, Jammas D, Chen XH, Kuban RJ, Ungethüm U, Krapfenbauer U, Herzel HP, Schäfer R, Walter J, Sers C. Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. Oncogene. 2006 Aug 10; 25(35):4890-903