firefoxA functional genomics database for energy microalgae (EnergyAlgaeDB; should be of significant value to a worldwide userbase for multiple disciplines, mainly for the following four reasons. (1) Microalgae have been considered as one promising feedstock for biofuel (liquid fuels such as TAG and gaseus fuels such as hydrogen) with a production scale potentially large enough to replace fossil diesel while simutaneously capture industrial CO2. However, the structural and functional diversity of microalgal genomes remain ill defined. For example, few oleaginous algal genomes were published to-date, although dozens of them are being sequenced across the world. Thus a database such as EnergyAlgaeDB is an essential community resource for cataloguing, annotation and distributing genomic information. (2) Algae exhibit tremendous ecological, evolutionary and organismal diversity that together constituted 40% of photosynthesis on earth. They are part of the green plant lineage (Viridiplantae), and diverged from the Streptophytes (land plants and their close relatives) over a billion years ago. Thus they represent an evolutionarily crucial domain of life. Therefore, a database such as EnergyAlgaeDB should also be of significant value to those interested in the eukaryotic ecology and evolution. (3) Up to now, few functional-genomics research model organisms for such “energy-algae” have been established. Traditional laboratory model-organisms for algal physiology such as Chlamydomonas reinhardtii ( do not produce large amount of oil and usually are not amenable to large-scale outdoor cultivation, thus new research models for robust biofuel production are urgently needed. A database such as EnergyAlgaeDB, as a centralized infrastructure for storing, integrating and cross-validating the various kinds of “omics” data, is one prerequisite for the research community to together establish such emerging new microalgal model organisms. (4) There are so far only a few existing publicly accessible databases on microalgae, and there has been no genomics database for the vast energy-algae despite of the rapidly emerging genomic resources. Most of the available databases for algae are providing ecological, phylogenetic and phenotypic curation of microalgal strains found in nature, yet do not provide any genomics or functional genomics information (e.g. Algae Resource Database,; AlgaeBase, The few that serve genomics resources are solely dedicated for Chlamydomonas reinhardtii, the existing laboratory research model organism (e.g.